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Management of myelodysplastic syndromes (MDS) continues to be difficult. The few therapies that have proven effective in reducing the morbidity and mortality associated with MDS have long-term effects. Therefore, these therapies should be initiated at the time of diagnosis, and patients should be followed with serial bone marrow examinations. Inappropriate therapy may result in rapid progression of the disease and premature death. Recent studies have shown that low-dose cytosine arabinoside (LD-Ara-C) can prolong the duration of remission in low-grade MDS. Combination therapy with LD-Ara-C plus cytosine and arabinoside, and LD-Ara-C plus cytosine and 5-azacitidine have also been shown to prolong survival in patients with MDS. Interferon-alpha given as a single agent or in combination with cytosine and 5-azacitidine has been shown to increase survival in patients with low-risk MDS. Patients with lower risk disease may also benefit from allogeneic bone marrow transplantation, although the use of bone marrow transplantation should be restricted to patients with a poor risk classification. Overall, there is no one treatment that can cure MDS; however, there are many other treatment options that may prolong the patient’s life and improve their quality of life.The prognostic significance of mismatch repair deficiency in renal cell carcinoma: a systematic review and meta-
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